| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Microsomal triglyceride transfer protein large subunit |
|---|
| Ligand | BDBM50184111 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_364710 (CHEMBL866306) |
|---|
| IC50 | 1.75±n/a nM |
|---|
| Citation |  Li, J; Bertinato, P; Cheng, H; Cole, BM; Bronk, BS; Jaynes, BH; Hickman, A; Haven, ML; Kolosko, NL; Barry, CJ; Manion, TB Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents. Bioorg Med Chem Lett16:3039-42 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Microsomal triglyceride transfer protein large subunit |
|---|
| Name: | Microsomal triglyceride transfer protein large subunit |
|---|
| Synonyms: | MTP | MTP_HUMAN | MTTP | Microsomal triglyceride transfer protein | Microsomal triglyceride transfer protein large subunit |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 99365.65 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_971724 |
|---|
| Residue: | 894 |
|---|
| Sequence: | MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRIS
SNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQ
RPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQA
HQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGL
NFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKG
CPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLV
DAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIG
SSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNA
LLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVR
TAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEM
VAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLH
GSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSA
SGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKN
RVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQF
EKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
|
|
|
|---|
| BDBM50184111 |
|---|
| n/a |
|---|
| Name | BDBM50184111 |
|---|
| Synonyms: | 4'-trifluoromethyl-biphenyl-2-carboxylic acid [2-methoxy-4-((S)-2-oxo-1-phenyl-2-pyrrolidin-1-yl-ethylcarbamoyl)-phenyl]-amide | CHEMBL210652 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H30F3N3O4 |
|---|
| Mol. Mass. | 601.6149 |
|---|
| SMILES | COc1cc(ccc1NC(=O)c1ccccc1-c1ccc(cc1)C(F)(F)F)C(=O)N[C@H](C(=O)N1CCCC1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
