| Reaction Details |
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 | Report a problem with these data |
| Target | Prostacyclin receptor |
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| Ligand | BDBM50184215 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_364764 (CHEMBL854186) |
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| Ki | >2000±n/a nM |
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| Citation |  Sturino, CF; Lachance, N; Boyd, M; Berthelette, C; Labelle, M; Li, L; Roy, B; Scheigetz, J; Tsou, N; Brideau, C; Cauchon, E; Carriere, MC; Denis, D; Greig, G; Kargman, S; Lamontagne, S; Mathieu, MC; Sawyer, N; Slipetz, D; O'Neill, G; Wang, Z; Zamboni, R; Metters, KM; Young, RN Identification of an indole series of prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett16:3043-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostacyclin receptor |
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| Name: | Prostacyclin receptor |
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| Synonyms: | PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40968.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The membranes prepared from human platelet were used in binding assay. |
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| Residue: | 386 |
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| Sequence: | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD
LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA
LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG
GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL
LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF
QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL
PPTQQSSGSAVGTSSKAEASVACSLC
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| BDBM50184215 |
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| n/a |
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| Name | BDBM50184215 |
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| Synonyms: | 2-(9-(4-chlorobenzyl)-6,8-difluoro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)acetic acid | CHEMBL208260 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H18ClF2NO2 |
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| Mol. Mass. | 389.823 |
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| SMILES | OC(=O)CC1CCCc2c1n(Cc1ccc(Cl)cc1)c1c(F)cc(F)cc21 |
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| Structure | 
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