Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50184357

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_338133 (CHEMBL867660)

IC50

2700±n/a nM

Citation

Mayorov, AV; Cai, M; Chandler, KB; Petrov, RR; Van Scoy, AR; Yu, Z; Tanaka, DK; Trivedi, D; Hruby, VJ Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem49:1946-52 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50184357

n/a

Name

BDBM50184357

Synonyms:

CHEMBL381739 | c[Nle-Pro-D-Phe-Arg-Trp-Glu]-NH2

Type

Small organic molecule

Emp. Form.

C42H57N11O7

Mol. Mass.

827.9715

SMILES

CCCC[C@@H]1NC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O)C(N)=O |wU:10.61,50.57,39.41,wD:28.30,14.14,4.3,(-3.21,-14.67,;-3.2,-16.21,;-2.12,-16.93,;-2.12,-18.45,;-.89,-19.15,;.81,-18.53,;.8,-16.99,;-.54,-16.22,;2.01,-16.21,;2.54,-14.93,;4.06,-14.72,;4.82,-16.05,;5.58,-17.38,;7.07,-16.97,;5.98,-18.86,;7.52,-18.86,;8.29,-20.2,;8.28,-21.74,;9.75,-22.22,;10.65,-20.98,;12.18,-20.84,;12.82,-19.44,;11.91,-18.18,;10.39,-18.34,;9.76,-19.73,;5.04,-20.08,;5.63,-21.51,;7.17,-21.5,;5.23,-22.98,;6.32,-24.07,;7.8,-23.67,;8.89,-24.76,;10.38,-24.36,;11.47,-25.45,;12.96,-25.05,;11.07,-26.94,;3.89,-23.75,;2.56,-22.97,;2.57,-21.43,;1.22,-23.73,;1.22,-25.27,;2.55,-26.04,;2.54,-27.58,;3.87,-28.35,;5.21,-27.59,;5.21,-26.04,;3.88,-25.27,;-.12,-22.96,;-1.45,-23.73,;-1.48,-25.27,;-2.98,-22.77,;-4.51,-22.93,;-5.14,-21.52,;-4,-20.49,;-2.66,-21.26,;-1.24,-20.67,;-.02,-21.42,;4.83,-13.38,;4.06,-12.05,;6.37,-13.39,)|

Structure