| Reaction Details |
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 | Report a problem with these data |
| Target | Dimer of Tryptase beta-2 |
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| Ligand | BDBM50184509 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_365130 (CHEMBL867493) |
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| IC50 | 5100±n/a nM |
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| Citation |  Miyazaki, Y; Kato, Y; Manabe, T; Shimada, H; Mizuno, M; Egusa, T; Ohkouchi, M; Shiromizu, I; Matsusue, T; Yamamoto, I Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors. Bioorg Med Chem Lett16:2986-90 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dimer of Tryptase beta-2 |
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| Name: | Dimer of Tryptase beta-2 |
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| Synonyms: | Tryptase beta-1/beta-2 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 365130 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| Component 2 |
| Name: | Tryptase beta-2 |
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| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30518.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_210702 |
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| Residue: | 275 |
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| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
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| BDBM50184509 |
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| n/a |
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| Name | BDBM50184509 |
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| Synonyms: | 1-(4-(aminomethyl)phenyl)-N-((1-(naphthalen-2-ylsulfonyl)piperidin-4-yl)methyl)piperidin-4-amine | CHEMBL207866 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H36N4O2S |
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| Mol. Mass. | 492.676 |
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| SMILES | NCc1ccc(cc1)N1CCC(CC1)NCC1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1 |
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| Structure | 
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