| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50185039 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_343377 (CHEMBL860697) |
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| IC50 | 3628±n/a nM |
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| Citation |  Kym, PR; Souers, AJ; Campbell, TJ; Lynch, JK; Judd, AS; Iyengar, R; Vasudevan, A; Gao, J; Freeman, JC; Wodka, D; Mulhern, M; Zhao, G; Wagaw, SH; Napier, JJ; Brodjian, S; Dayton, BD; Reilly, RM; Segreti, JA; Fryer, RM; Preusser, LC; Reinhart, GA; Hernandez, L; Marsh, KC; Sham, HL; Collins, CA; Polakowski, JS Screening for cardiovascular safety: a structure-activity approach for guiding lead selection of melanin concentrating hormone receptor 1 antagonists. J Med Chem49:2339-52 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50185039 |
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| n/a |
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| Name | BDBM50185039 |
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| Synonyms: | 2-(4-Methoxyphenyl)-N-[1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide | CHEMBL205106 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26N4O2 |
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| Mol. Mass. | 378.4674 |
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| SMILES | COc1ccc(CC(=O)Nc2ccc3cnn(CCN4CCCC4)c3c2)cc1 |
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| Structure | 
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