| Reaction Details |
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 | Report a problem with these data |
| Target | Advanced glycosylation end product-specific receptor |
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| Ligand | BDBM50249580 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2250937 (CHEMBL5165147) |
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| Kd | 13±n/a nM |
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| Citation |  Zhang, C; Wang, L; Xu, Y; Huang, Y; Huang, J; Zhu, J; Wang, W; Li, W; Sun, A; Li, X; Zhang, H; Li, J Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression. Eur J Med Chem236:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Advanced glycosylation end product-specific receptor |
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| Name: | Advanced glycosylation end product-specific receptor |
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| Synonyms: | AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42800.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1339877 |
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| Residue: | 404 |
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| Sequence: | MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
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| BDBM50249580 |
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| n/a |
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| Name | BDBM50249580 |
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| Synonyms: | Azeliragon | PF-04494700 | TTP448 | US11524942, Compound I |
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| Type | Small organic molecule |
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| Emp. Form. | C32H38ClN3O2 |
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| Mol. Mass. | 532.116 |
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| SMILES | CCCCc1nc(cn1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCCN(CC)CC)cc1 |
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| Structure | 
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