| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Advanced glycosylation end product-specific receptor |
|---|
| Ligand | BDBM50605291 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2250939 (CHEMBL5165149) |
|---|
| IC50 | 16050±n/a nM |
|---|
| Citation |  Zhang, C; Wang, L; Xu, Y; Huang, Y; Huang, J; Zhu, J; Wang, W; Li, W; Sun, A; Li, X; Zhang, H; Li, J Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression. Eur J Med Chem236:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Advanced glycosylation end product-specific receptor |
|---|
| Name: | Advanced glycosylation end product-specific receptor |
|---|
| Synonyms: | AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 42800.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1339877 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
|
|
|
|---|
| BDBM50605291 |
|---|
| n/a |
|---|
| Name | BDBM50605291 |
|---|
| Synonyms: | CHEMBL5170035 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H33ClN4OS |
|---|
| Mol. Mass. | 581.17 |
|---|
| SMILES | CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)C1CCN(Cc2c[nH]c3ccc(cc23)C#N)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
