Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50187222 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_356302 (CHEMBL869357) |
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IC50 | 2100±n/a nM |
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Citation | Gopalsamy, A; Chopra, R; Lim, K; Ciszewski, G; Shi, M; Curran, KJ; Sukits, SF; Svenson, K; Bard, J; Ellingboe, JW; Agarwal, A; Krishnamurthy, G; Howe, AY; Orlowski, M; Feld, B; O'Connell, J; Mansour, TS Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem49:3052-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50187222 |
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n/a |
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Name | BDBM50187222 |
Synonyms: | (S)-1-(3-chloro-5-fluoro-2-hydroxyphenylsulfonyl)pyrrolidine-2-carboxylic acid | CHEMBL207500 |
Type | Small organic molecule |
Emp. Form. | C11H11ClFNO5S |
Mol. Mass. | 323.725 |
SMILES | OC(=O)[C@@H]1CCCN1S(=O)(=O)c1cc(F)cc(Cl)c1O |
Structure |
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