| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50605623 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252312 (CHEMBL5166522) |
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| IC50 | 2600±n/a nM |
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| Citation |  Govender, P; Müller, R; Singh, K; Reddy, V; Eyermann, CJ; Fienberg, S; Ghorpade, SR; Koekemoer, L; Myrick, A; Schnappinger, D; Engelhart, C; Meshanni, J; Byl, JAW; Osheroff, N; Singh, V; Chibale, K; Basarab, GS Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. J Med Chem65:6903-6925 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | 5.6.2.2 | DNA gyrase subunit B | GYRB_MYCTU | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74087.83 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | ChEMBL_109655 |
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| Residue: | 675 |
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| Sequence: | MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
YATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGL
HGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVF
ETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAES
TAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISV
KVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKK
INKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARR
SFITRNAKDVRFLDV
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| BDBM50605623 |
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| n/a |
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| Name | BDBM50605623 |
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| Synonyms: | CHEMBL5203837 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24FN5O7 |
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| Mol. Mass. | 501.4644 |
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| SMILES | [H][C@]12[C@H](C)O[C@H](C)CN1c1c(CC22C(=O)NC(=O)NC2=O)cc2c(OC[C@@H]3CCC(=O)N3)noc2c1F |r| |
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| Structure | 
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