Reaction Details |
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Target | Thyroid hormone receptor alpha |
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Ligand | BDBM50605644 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2252577 (CHEMBL5166787) |
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EC50 | 15±n/a nM |
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Citation | Li, Q; Yao, B; Zhao, S; Lu, Z; Zhang, Y; Xiang, Q; Wu, X; Yu, H; Zhang, C; Li, J; Zhuang, X; Wu, D; Li, Y; Xu, Y Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor ? Agonist. J Med Chem65:7193-7211 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid hormone receptor alpha |
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Name: | Thyroid hormone receptor alpha |
Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
Type: | Receptor |
Mol. Mass.: | 54818.00 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
Residue: | 490 |
Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
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BDBM50605644 |
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n/a |
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Name | BDBM50605644 |
Synonyms: | CHEMBL5209093 |
Type | Small organic molecule |
Emp. Form. | C18H13BrN2O5 |
Mol. Mass. | 417.21 |
SMILES | OC(=O)CNC(=O)c1nc(Br)c2cc(Oc3ccccc3)ccc2c1O |
Structure |
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