| Reaction Details |
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 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
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| Ligand | BDBM50605655 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252578 (CHEMBL5166788) |
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| EC50 | 6.9±n/a nM |
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| Citation |  Li, Q; Yao, B; Zhao, S; Lu, Z; Zhang, Y; Xiang, Q; Wu, X; Yu, H; Zhang, C; Li, J; Zhuang, X; Wu, D; Li, Y; Xu, Y Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor ? Agonist. J Med Chem65:7193-7211 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyroid hormone receptor beta |
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| Name: | Thyroid hormone receptor beta |
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| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
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| Type: | Receptor |
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| Mol. Mass.: | 52793.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
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| Residue: | 461 |
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| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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| BDBM50605655 |
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| n/a |
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| Name | BDBM50605655 |
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| Synonyms: | CHEMBL5207186 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22N2O7 |
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| Mol. Mass. | 486.4728 |
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| SMILES | CCOc1nc(C(=O)NCC(O)=O)c(O)c2ccc(Oc3ccc(cc3)C(=O)c3ccccc3)cc12 |
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| Structure | 
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