| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50188343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_389337 (CHEMBL868650) |
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| IC50 | 2±n/a nM |
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| Citation |  Sabat, M; Vanrens, JC; Brugel, TA; Maier, J; Laufersweiler, MJ; Golebiowski, A; De, B; Easwaran, V; Hsieh, LC; Rosegen, J; Berberich, S; Suchanek, E; Janusz, MJ The development of novel 1,2-dihydro-pyrimido[4,5-c]pyridazine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett16:4257-61 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50188343 |
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| n/a |
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| Name | BDBM50188343 |
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| Synonyms: | 4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethoxy)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-one | CHEMBL379517 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H28Cl2N6O2 |
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| Mol. Mass. | 539.456 |
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| SMILES | CCN(CC)CCOc1ccc(Nc2ncc3C=C(N4N(CCC4=O)c3n2)c2c(Cl)cccc2Cl)cc1 |c:17| |
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| Structure | 
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