| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent glycine transporter 2 |
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| Ligand | BDBM50188803 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_378749 (CHEMBL871494) |
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| EC50 | 25000±n/a nM |
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| Citation |  Alberati, D; Hainzl, D; Jolidon, S; Krafft, EA; Kurt, A; Maier, A; Pinard, E; Thomas, AW; Zimmerli, D Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability. Bioorg Med Chem Lett16:4311-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent glycine transporter 2 |
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| Name: | Sodium- and chloride-dependent glycine transporter 2 |
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| Synonyms: | GLYT2 | Glycine transporter 2 | NET1 | SC6A5_HUMAN | SLC6A5 | Sodium- and chloride-dependent glycine transporter 2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 87438.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glycine-2-transporter 0 HUMAN::Q9Y345 |
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| Residue: | 797 |
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| Sequence: | MDCSAPKEMNKLPANSPEAAAAQGHPDGPCAPRTSPEQELPAAAAPPPPRVPRSASTGAQ
TFQSADARACEAERPGVGSCKLSSPRAQAASAALRDLREAQGAQASPPPGSSGPGNALHC
KIPFLRGPEGDANVSVGKGTLERNNTPVVGWVNMSQSTVVLATDGITSVLPGSVATVATQ
EDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALA
GLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFA
SFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNVTMVNFT
SQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSGK
VVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSA
AWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVAD
QGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRT
HKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQR
FCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWL
MLACSVIWIPIMFVIKMHLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTS
SLGLKLPVKDLELGTQC
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| BDBM50188803 |
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| n/a |
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| Name | BDBM50188803 |
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| Synonyms: | (S)-4-phenyl-8-((1R,2R)-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one | CHEMBL379860 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N2O |
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| Mol. Mass. | 388.5451 |
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| SMILES | O=C1NC[C@@H](c2ccccc2)C11CCN(CC1)[C@@H]1CCCC[C@@H]1c1ccccc1 |
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| Structure | 
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