| Reaction Details |
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 | Report a problem with these data |
| Target | Protein AF-9 |
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| Ligand | BDBM50606145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2253822 (CHEMBL5168032) |
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| Ki | 29±n/a nM |
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| Citation |  Yuan, Y; Du, L; Tan, R; Yu, Y; Jiang, J; Yao, A; Luo, J; Tang, R; Xiao, Y; Sun, H Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem65:7770-7785 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein AF-9 |
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| Name: | Protein AF-9 |
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| Synonyms: | AF9 | AF9_HUMAN | ALL1-fused gene from chromosome 9 protein | MLLT3 | Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein | Protein AF-9 | YEATS domain-containing protein 3 | YEATS3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63368.78 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118006 |
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| Residue: | 568 |
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| Sequence: | MASSCAVQVKLELGHRAQVRKKPTVEGFTHDWMVFVRGPEHSNIQHFVEKVVFHLHESFP
RPKRVCKDPPYKVEESGYAGFILPIEVYFKNKEEPRKVRFDYDLFLHLEGHPPVNHLRCE
KLTFNNPTEDFRRKLLKAGGDPNRSIHTSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS
SSSSSSSSSSTSFSKPHKLMKEHKEKPSKDSREHKSAFKEPSRDHNKSSKESSKKPKENK
PLKEEKIVPKMAFKEPKPMSKEPKPDSNLLTITSGQDKKAPSKRPPISDSEELSAKKRKK
SSSEALFKSFSSAPPLILTCSADKKQIKDKSHVKMGKVKIESETSEKKKSTLPPFDDIVD
PNDSDVEENISSKSDSEQPSPASSSSSSSSSFTPSQTRQQGPLRSIMKDLHSDDNEEESD
EVEDNDNDSEMERPVNRGGSRSRRVSLSDGSDSESSSASSPLHHEPPPPLLKTNNNQILE
VKSPIKQSKSDKQIKNGECDKAYLDELVELHRRLMTLRERHILQQIVNLIEETGHFHITN
TTFDFDLCSLDKTTVRKLQSYLETSGTS
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| BDBM50606145 |
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| n/a |
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| Name | BDBM50606145 |
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| Synonyms: | CHEMBL5190103 |
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| Type | Small organic molecule |
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| Emp. Form. | C46H67N9O6 |
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| Mol. Mass. | 842.0809 |
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| SMILES | CC(C)C[C@H](NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CN)C(=O)N[C@@H](CC1CCCC1)C(=O)N[C@@H](C(C)C)c1nc2cccc(-c3ccccc3)c2[nH]1 |r| |
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| Structure | 
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