| Reaction Details |
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 | Report a problem with these data |
| Target | Glucagon-like peptide 1 receptor |
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| Ligand | BDBM349662 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2254308 (CHEMBL5168518) |
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| EC50 | >20000±n/a nM |
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| Citation |  Griffith, DA; Edmonds, DJ; Fortin, JP; Kalgutkar, AS; Kuzmiski, JB; Loria, PM; Saxena, AR; Bagley, SW; Buckeridge, C; Curto, JM; Derksen, DR; Dias, JM; Griffor, MC; Han, S; Jackson, VM; Landis, MS; Lettiere, D; Limberakis, C; Liu, Y; Mathiowetz, AM; Patel, JC; Piotrowski, DW; Price, DA; Ruggeri, RB; Tess, DA A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J Med Chem65:8208-8226 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucagon-like peptide 1 receptor |
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| Name: | Glucagon-like peptide 1 receptor |
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| Synonyms: | GLP1R_RAT | Glp1r | Glpr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52889.73 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_855307 |
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| Residue: | 463 |
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| Sequence: | MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGL
FCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPW
RDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIH
LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAAN
YYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRN
SNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLL
GTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERW
RLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
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| BDBM349662 |
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| n/a |
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| Name | BDBM349662 |
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| Synonyms: | 2-{[4-(6-{[(4-cyano-2-fluorophenyl)(methyl-d2)]oxy}pyridin-2-yl)piperidin-1-yl]methyl}-1-[(2S)-oxetan-2-ylmethyl]-1H-benzimidazole-6-carboxylic acid | US10208019, Example 1A-09 | US10208019, Example 4A-01 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H30FN5O4 |
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| Mol. Mass. | 555.5994 |
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| SMILES | OC(=O)c1ccc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 |
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| Structure | 
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