Reaction Details |
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Target | Caspase-8 |
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Ligand | BDBM50189364 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_388620 (CHEMBL865480) |
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IC50 | 2600±n/a nM |
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Citation | Soper, DL; Sheville, J; O'Neil, SV; Wang, Y; Laufersweiler, MC; Oppong, KA; Wos, JA; Ellis, CD; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; De, B; Demuth, TP Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett16:4233-6 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Caspase-8 |
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Name: | Caspase-8 |
Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
Type: | Enzyme |
Mol. Mass.: | 55373.89 |
Organism: | Homo sapiens (Human) |
Description: | Q14790 |
Residue: | 479 |
Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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BDBM50189364 |
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n/a |
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Name | BDBM50189364 |
Synonyms: | CHEMBL211512 | N'-(1-(((3S)-2-hydroxy-5-oxo-tetrahydrofuran-3-yl)carbamoyl)cyclohexanecarbonyl)-2-naphthohydrazide |
Type | Small organic molecule |
Emp. Form. | C23H25N3O6 |
Mol. Mass. | 439.4611 |
SMILES | OC1OC(=O)C[C@@H]1NC(=O)C1(CCCCC1)C(=O)NNC(=O)c1ccc2ccccc2c1 |
Structure |
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