| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-1 |
|---|
| Ligand | BDBM50189369 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_388619 (CHEMBL865479) |
|---|
| IC50 | 260±n/a nM |
|---|
| Citation |  Soper, DL; Sheville, J; O'Neil, SV; Wang, Y; Laufersweiler, MC; Oppong, KA; Wos, JA; Ellis, CD; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; De, B; Demuth, TP Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem Lett16:4233-6 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-1 |
|---|
| Name: | Caspase-1 |
|---|
| Synonyms: | CASP1 | CASP1_HUMAN | Caspase | Caspase 1 | ICE | IL1BC | IL1BCE | Interleukin-1 beta convertase | Interleukin-1 beta-converting enzyme |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 45154.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P29466 |
|---|
| Residue: | 404 |
|---|
| Sequence: | MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
|
|
|
|---|
| BDBM50189369 |
|---|
| n/a |
|---|
| Name | BDBM50189369 |
|---|
| Synonyms: | CHEMBL386240 | N'-(1-(((3S)-2-hydroxy-5-oxo-tetrahydrofuran-3-yl)carbamoyl)cyclobutanecarbonyl)-3-methoxybenzohydrazide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21N3O7 |
|---|
| Mol. Mass. | 391.3752 |
|---|
| SMILES | COc1cccc(c1)C(=O)NNC(=O)C1(CCC1)C(=O)N[C@H]1CC(=O)OC1O |
|---|
| Structure | 
|
|---|
Search and Browse
