Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50189688 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_368413 (CHEMBL870503) |
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IC50 | 51±n/a nM |
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Citation | Combs, AP; Zhu, W; Crawley, ML; Glass, B; Polam, P; Sparks, RB; Modi, D; Takvorian, A; McLaughlin, E; Yue, EW; Wasserman, Z; Bower, M; Wei, M; Rupar, M; Ala, PJ; Reid, BM; Ellis, D; Gonneville, L; Emm, T; Taylor, N; Yeleswaram, S; Li, Y; Wynn, R; Burn, TC; Hollis, G; Liu, PC; Metcalf, B Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic. J Med Chem49:3774-89 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50189688 |
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n/a |
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Name | BDBM50189688 |
Synonyms: | CHEMBL206950 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(1,1,3-trioxo-1lambda*6*-isothiazolidin-5-yl)-phenyl]-ethyl}-3,5-dichloro-benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C24H20Cl2N4O5S2 |
Mol. Mass. | 579.475 |
SMILES | Clc1cc(Cl)cc(c1)S(=O)(=O)NC(Cc1ccc(cc1)C1CC(=O)NS1(=O)=O)c1nc2ccccc2[nH]1 |
Structure |
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