| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50190846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_405761 (CHEMBL869873) |
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| IC50 | 2±n/a nM |
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| Citation |  Finke, PE; Meurer, LC; Levorse, DA; Mills, SG; Maccoss, M; Sadowski, S; Cascieri, MA; Tsao, KL; Chicchi, GG; Metzger, JM; Macintyre, DE Cyclopentane-based human NK1 antagonists. Part 1: discovery and initial SAR. Bioorg Med Chem Lett16:4497-503 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50190846 |
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| n/a |
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| Name | BDBM50190846 |
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| Synonyms: | (+/-)-trans-5-((((3-(3,5-bis(trifluoromethyl)benzyloxy)-2-phenylcyclopentyl)methyl)(methyl)amino)methyl)-2H-1,2,4-triazol-3(4H)-one | CHEMBL209627 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26F6N4O2 |
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| Mol. Mass. | 528.49 |
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| SMILES | CN(C[C@@H]1CC[C@H](OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@H]1c1ccccc1)Cc1n[nH]c(=O)[nH]1 |
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| Structure | 
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