| Reaction Details |
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 | Report a problem with these data |
| Target | C-C motif chemokine 2 |
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| Ligand | BDBM50607752 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2263139 (CHEMBL5218150) |
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| IC50 | 398±n/a nM |
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| Citation |  Humphreys, PG; Anderson, NA; Bamborough, P; Baxter, A; Chung, CW; Cookson, R; Craggs, PD; Dalton, T; Fournier, JCL; Gordon, LJ; Gray, HF; Gray, MW; Gregory, R; Hirst, DJ; Jamieson, C; Jones, KL; Kessedjian, H; Lugo, D; McGonagle, G; Patel, VK; Patten, C; Poole, DL; Prinjha, RK; Ramirez-Molina, C; Rioja, I; Seal, G; Stafford, KAJ; Shah, RR; Tape, D; Theodoulou, NH; Tomlinson, L; Ukuser, S; Wall, ID; Wellaway, N; White, G Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432. J Med Chem65:15174-15207 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C motif chemokine 2 |
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| Name: | C-C motif chemokine 2 |
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| Synonyms: | CCL2 | CCL2_HUMAN | HC11 | MCAF | MCP-1 | MCP1 | Monocyte chemoattractant protein 1 | Monocyte chemotactic and activating factor | Monocyte chemotactic protein 1 | Monocyte secretory protein JE | SCYA2 | Small-inducible cytokine A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 11032.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1363188 |
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| Residue: | 99 |
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| Sequence: | MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCP
KEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
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| BDBM50607752 |
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| n/a |
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| Name | BDBM50607752 |
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| Synonyms: | CHEMBL5220099 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17NO3S |
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| Mol. Mass. | 279.355 |
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| SMILES | CCS(=O)(=O)c1ccc2[C@@H](C)C(=O)N(C)C=Cc2c1 |r,c:15| |
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| Structure | 
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