| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1 |
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| Ligand | BDBM50191832 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_397780 (CHEMBL856311) |
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| IC50 | 350±n/a nM |
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| Citation |  Atwal, KS; O'Neil, SV; Ahmad, S; Doweyko, L; Kirby, M; Dorso, CR; Chandrasena, G; Chen, BC; Zhao, R; Zahler, R Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors. Bioorg Med Chem Lett16:4796-9 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 1 |
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| Name: | Sodium/hydrogen exchanger 1 |
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| Synonyms: | APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 90771.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_862405 |
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| Residue: | 815 |
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| Sequence: | MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDV
TTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFV
VALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITID
PASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTP
APSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
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| BDBM50191832 |
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| n/a |
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| Name | BDBM50191832 |
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| Synonyms: | 5-(3-methoxyphenyl)-4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)pyrimidine | CHEMBL450633 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N5O |
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| Mol. Mass. | 349.4295 |
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| SMILES | COc1cccc(c1)-c1cncnc1N1CCC(CC1)c1[nH]cnc1C |
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| Structure | 
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