| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 1 |
|---|
| Ligand | BDBM50191833 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_397780 (CHEMBL856311) |
|---|
| IC50 | 21±n/a nM |
|---|
| Citation |  Atwal, KS; O'Neil, SV; Ahmad, S; Doweyko, L; Kirby, M; Dorso, CR; Chandrasena, G; Chen, BC; Zhao, R; Zahler, R Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors. Bioorg Med Chem Lett16:4796-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/hydrogen exchanger 1 |
|---|
| Name: | Sodium/hydrogen exchanger 1 |
|---|
| Synonyms: | APNH | APNH1 | NHE-1 | NHE1 | Na(+)/H(+) antiporter, amiloride-sensitive | Na(+)/H(+) exchanger 1 | SL9A1_HUMAN | SLC9A1 | Solute carrier family 9 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 90771.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_862405 |
|---|
| Residue: | 815 |
|---|
| Sequence: | MVLRSGICGLSPHRIFPSLLVVVALVGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDV
TTAPPEVTPESRPVNHSVTDHGMKPRKAFPVLGIDYTHVRTPFEISLWILLACLMKIGFH
VIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLR
QFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPV
AVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFANYEHVGIVDIFLGFLSFFV
VALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASG
VVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLF
CLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLF
LTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGH
YGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSA
VSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQKTRQRLRSYNRHTLVADPYE
EAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITID
PASPQSPESVDLVNEELKGKVLGLSRDPAKVAEEDEDDDGGIMMRSKETSSPGTDDVFTP
APSDSPSSQRIQRCLSDPGPHPEPGEGEPFFPKGQ
|
|
|
|---|
| BDBM50191833 |
|---|
| n/a |
|---|
| Name | BDBM50191833 |
|---|
| Synonyms: | 5-(4-fluoro-3-methylphenyl)-4-(4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl)pyrimidine | CHEMBL376979 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22FN5 |
|---|
| Mol. Mass. | 351.4206 |
|---|
| SMILES | Cc1nc[nH]c1C1CCN(CC1)c1ncncc1-c1ccc(F)c(C)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
