Reaction Details |
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Target | Mitogen-activated protein kinase kinase kinase kinase 2 |
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Ligand | BDBM466724 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2266087 |
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IC50 | 819±n/a nM |
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Citation | Sokolsky, A; Vechorkin, O; Hummel, JR; Styduhar, ED; Wang, A; Nguyen, MH; Ye, HF; Liu, K; Zhang, K; Pan, J; Ye, Q; Atasoylu, O; Behshad, E; He, X; Conlen, P; Stump, K; Ye, M; Diamond, S; Covington, M; Yeleswaram, S; Yao, W Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1). ACS Med Chem Lett14:116-122 (2023) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase kinase kinase kinase 2 |
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Name: | Mitogen-activated protein kinase kinase kinase kinase 2 |
Synonyms: | 2.7.11.1 | B lymphocyte serine/threonine-protein kinase | GC kinase | GCK | Germinal center kinase | M4K2_HUMAN | MAP4K2 | MAPK/ERK kinase kinase kinase 2 | MEK kinase kinase 2 | MEKKK 2 | RAB8IP | Rab8-interacting protein |
Type: | n/a |
Mol. Mass.: | 91551.35 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 820 |
Sequence: | MALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQ
EITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREA
LKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAP
EVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKT
RWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTPSPE
DCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVKFGAPRRKETDPLNEPWEEEWTLLG
KEELSGSLLQSVQEALEERSLTIRSASEFQELDSPDDTMGTIKRAPFLGPLPTDPPAEEP
LSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMGACFSKVFNG
CPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCVNNVL
LSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQ
CRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAGMLEPLVLDGKE
LPQVCVGAEGPEGPGCRVLFHVLPLEAGLTPDILIPPEGIPGSAQQVIQVDRDTILVSFE
RCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNEVTQEITD
ETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY
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BDBM466724 |
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n/a |
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Name | BDBM466724 |
Synonyms: | US10800761, Example 43 | US11731958, Example 43 |
Type | Small organic molecule |
Emp. Form. | C29H29FN6O3 |
Mol. Mass. | 528.5774 |
SMILES | COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc(cc1N1C[C@@H](N)C[C@H]1CO)-c1cccnc1C |r| |
Structure |
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