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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Ligand | BDBM50193787 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_424105 (CHEMBL856751) | ||
| IC50 | 260±n/a nM | ||
| Citation |  Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett16:5555-60 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 11-beta-hydroxysteroid dehydrogenase 1 | |||
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 32409.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P28845 | ||
| Residue: | 292 | ||
| Sequence: |
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| BDBM50193787 | |||
| n/a | |||
| Name | BDBM50193787 | ||
| Synonyms: | 4-[3,3-dmethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-N-hydroxy-adamantane-1-carboxamidine | CHEMBL267734 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H31F3N4O3 | ||
| Mol. Mass. | 480.5231 | ||
| SMILES | CC1(C)C(COc2ccc(cn2)C(F)(F)F)CN([C@H]2C3CC4CC2C[C@](C4)(C3)C(=N)NO)C1=O |wU:18.18,wD:25.31,TLB:18:19:26:22.23.24,17:18:26.21.22:24,THB:20:21:24:27.19.18,20:19:26.21.22:24,18:23:26:27.20.19,(24.81,-1.12,;23.49,-.36,;23.94,1.11,;23.01,-1.82,;23.91,-3.07,;25.46,-3.04,;26.25,-4.36,;25.51,-5.7,;26.31,-7.02,;27.85,-6.99,;28.59,-5.63,;27.79,-4.31,;28.6,-8.31,;29.36,-9.64,;27.27,-9.07,;29.93,-7.54,;21.46,-1.82,;20.99,-.36,;19.53,.11,;18.21,-.47,;16.68,.12,;16.63,1.65,;18.07,2.18,;19.53,1.65,;18.54,2.83,;17.1,2.24,;15.69,2.87,;17.23,.7,;17.09,3.78,;15.76,4.55,;18.42,4.57,;18.41,6.1,;22.24,.55,;22.24,2.09,)| | ||
| Structure | 
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