Reaction Details |
| Report a problem with these data |
Target | 11-beta-hydroxysteroid dehydrogenase 1 |
---|
Ligand | BDBM50193790 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_424103 (CHEMBL856749) |
---|
IC50 | 62±n/a nM |
---|
Citation | Yeh, VS; Kurukulasuriya, R; Fung, S; Monzon, K; Chiou, W; Wang, J; Stolarik, D; Imade, H; Shapiro, R; Knourek-Segel, V; Bush, E; Wilcox, D; Nguyen, PT; Brune, M; Jacobson, P; Link, JT Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett16:5555-60 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
11-beta-hydroxysteroid dehydrogenase 1 |
---|
Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
Type: | Enzyme |
Mol. Mass.: | 32369.70 |
Organism: | Mus musculus (mouse) |
Description: | P50172 |
Residue: | 292 |
Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
|
|
|
BDBM50193790 |
---|
n/a |
---|
Name | BDBM50193790 |
Synonyms: | 6-((1-cycloheptyl-4,4-dimethyl-5-oxopyrrolidin-3-yl)methoxy)nicotinonitrile | CHEMBL384650 |
Type | Small organic molecule |
Emp. Form. | C20H27N3O2 |
Mol. Mass. | 341.4473 |
SMILES | CC1(C)C(COc2ccc(cn2)C#N)CN(C2CCCCCC2)C1=O |
Structure |
|