Reaction Details |
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Target | Glycogen phosphorylase, liver form |
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Ligand | BDBM50194420 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_424360 (CHEMBL909563) |
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IC50 | 23±n/a nM |
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Citation | Whittamore, PR; Addie, MS; Bennett, SN; Birch, AM; Butters, M; Godfrey, L; Kenny, PW; Morley, AD; Murray, PM; Oikonomakos, NG; Otterbein, LR; Pannifer, AD; Parker, JS; Readman, K; Siedlecki, PS; Schofield, P; Stocker, A; Taylor, MJ; Townsend, LA; Whalley, DP; Whitehouse, J Novel thienopyrrole glycogen phosphorylase inhibitors: synthesis, in vitro SAR and crystallographic studies. Bioorg Med Chem Lett16:5567-71 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, liver form |
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Name: | Glycogen phosphorylase, liver form |
Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
Type: | Homodimer |
Mol. Mass.: | 97153.98 |
Organism: | Homo sapiens (Human) |
Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
Residue: | 847 |
Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
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BDBM50194420 |
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n/a |
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Name | BDBM50194420 |
Synonyms: | (S)-2,3-dibromo-N-(1-(dimethylamino)-1-oxo-3-phenylpropan-2-yl)-4H-thieno[3,2-b]pyrrole-5-carboxamide | CHEMBL217993 |
Type | Small organic molecule |
Emp. Form. | C18H17Br2N3O2S |
Mol. Mass. | 499.219 |
SMILES | CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2sc(Br)c(Br)c2[nH]1 |
Structure |
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