Reaction Details |
| Report a problem with these data |
Target | Mitogen-activated protein kinase kinase kinase 8 |
---|
Ligand | BDBM50195012 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_424645 (CHEMBL855706) |
---|
IC50 | 19000±n/a nM |
---|
Citation | Hu, Y; Green, N; Gavrin, LK; Janz, K; Kaila, N; Li, HQ; Thomason, JR; Cuozzo, JW; Hall, JP; Hsu, S; Nickerson-Nutter, C; Telliez, JB; Lin, LL; Tam, S Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis. Bioorg Med Chem Lett16:6067-72 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Mitogen-activated protein kinase kinase kinase 8 |
---|
Name: | Mitogen-activated protein kinase kinase kinase 8 |
Synonyms: | C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 52916.89 |
Organism: | Homo sapiens (Human) |
Description: | P41279 |
Residue: | 467 |
Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
|
|
|
BDBM50195012 |
---|
n/a |
---|
Name | BDBM50195012 |
Synonyms: | 6-((1H-imidazol-4-yl)methylamino)-4-(3-chloro-4-fluorophenylamino)-2-methylquinoline-3-carbonitrile | CHEMBL223587 |
Type | Small organic molecule |
Emp. Form. | C21H16ClFN6 |
Mol. Mass. | 406.843 |
SMILES | Cc1nc2ccc(NCc3cnc[nH]3)cc2c(Nc2ccc(F)c(Cl)c2)c1C#N |
Structure |
|