Reaction Details |
| Report a problem with these data |
Target | Tyrosine-protein kinase Lck |
---|
Ligand | BDBM50195351 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_424915 (CHEMBL908547) |
---|
IC50 | 3±n/a nM |
---|
Citation | Sabat, M; VanRens, JC; Laufersweiler, MJ; Brugel, TA; Maier, J; Golebiowski, A; De, B; Easwaran, V; Hsieh, LC; Walter, RL; Mekel, MJ; Evdokimov, A; Janusz, MJ The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg Med Chem Lett16:5973-7 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosine-protein kinase Lck |
---|
Name: | Tyrosine-protein kinase Lck |
Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
Type: | n/a |
Mol. Mass.: | 57987.83 |
Organism: | Homo sapiens (Human) |
Description: | P06239 |
Residue: | 509 |
Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
|
|
|
BDBM50195351 |
---|
n/a |
---|
Name | BDBM50195351 |
Synonyms: | 1-(3-(2,5-dimethylbenzyl)-5-(3-cyclohexylpropyl)phenyl)-1H-indene | CHEMBL220645 |
Type | Small organic molecule |
Emp. Form. | C24H26N6O3 |
Mol. Mass. | 446.5016 |
SMILES | Cc1ccc(O)cc1Nc1cc(OCCN2CCOCC2)nc(n1)-n1cnc2ccccc12 |
Structure |
|