| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin/cholecystokinin type B receptor |
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| Ligand | BDBM50196149 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_418719 (CHEMBL912951) |
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| Ki | >10000±n/a nM |
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| Citation |  Allison, BD; Phuong, VK; McAtee, LC; Rosen, M; Morton, M; Prendergast, C; Barrett, T; Lagaud, G; Freedman, J; Li, L; Wu, X; Venkatesan, H; Pippel, M; Woods, C; Rizzolio, MC; Hack, M; Hoey, K; Deng, X; King, C; Shankley, NP; Rabinowitz, MH Identification and optimization of anthranilic sulfonamides as novel, selective cholecystokinin-2 receptor antagonists. J Med Chem49:6371-90 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin/cholecystokinin type B receptor |
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| Name: | Gastrin/cholecystokinin type B receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50196149 |
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| n/a |
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| Name | BDBM50196149 |
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| Synonyms: | 4-[2-[(2,1,3-benzothiadiazol-4-ylsulfonyl)amino]benzoyl]-morpholine | CHEMBL217276 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N4O4S2 |
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| Mol. Mass. | 404.463 |
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| SMILES | O=C(N1CCOCC1)c1ccccc1NS(=O)(=O)c1cccc2nsnc12 |
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| Structure | 
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