| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesterol 24-hydroxylase |
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| Ligand | BDBM50609178 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2277110 |
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| IC50 | 93±n/a nM |
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| Citation |  Koike, T; Yoshikawa, M; Ando, HK; Farnaby, W; Nishi, T; Watanabe, E; Yano, J; Miyamoto, M; Kondo, S; Ishii, T; Kuroita, T Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J Med Chem64:12228-12244 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesterol 24-hydroxylase |
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| Name: | Cholesterol 24-hydroxylase |
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| Synonyms: | CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H) |
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| Type: | Protein |
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| Mol. Mass.: | 56834.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y6A2 |
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| Residue: | 500 |
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| Sequence: | MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
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| BDBM50609178 |
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| n/a |
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| Name | BDBM50609178 |
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| Synonyms: | CHEMBL5288871 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H25N3O |
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| Mol. Mass. | 371.4748 |
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| SMILES | Cc1ccc(-c2ccncc2)c(c1)C(=O)N1CCN(Cc2ccccc2)CC1 |
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| Structure | 
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