Reaction Details |
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Target | Cholesterol 24-hydroxylase |
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Ligand | BDBM50609183 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2277110 |
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IC50 | 74±n/a nM |
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Citation | Koike, T; Yoshikawa, M; Ando, HK; Farnaby, W; Nishi, T; Watanabe, E; Yano, J; Miyamoto, M; Kondo, S; Ishii, T; Kuroita, T Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H). J Med Chem64:12228-12244 (2021) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Cholesterol 24-hydroxylase |
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Name: | Cholesterol 24-hydroxylase |
Synonyms: | CP46A_HUMAN | CYP46 | CYP46A1 | Cholesterol 24-hydroxylase (CH24H) |
Type: | Protein |
Mol. Mass.: | 56834.45 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y6A2 |
Residue: | 500 |
Sequence: | MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
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BDBM50609183 |
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n/a |
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Name | BDBM50609183 |
Synonyms: | CHEMBL5282243 |
Type | Small organic molecule |
Emp. Form. | C26H28N2O2 |
Mol. Mass. | 400.5127 |
SMILES | COC1(Cc2ccccc2)CCN(CC1)C(=O)c1cc(C)ccc1-c1ccncc1 |
Structure |
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