| Reaction Details |
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 | Report a problem with these data |
| Target | Histone-arginine methyltransferase CARM1 |
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| Ligand | BDBM50609312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2277360 |
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| IC50 | 5.1±n/a nM |
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| Citation |  Zhang, Z; Guo, Z; Xu, X; Cao, D; Yang, H; Li, Y; Shi, Q; Du, Z; Guo, X; Wang, X; Chen, D; Zhang, Y; Chen, L; Zhou, K; Li, J; Geng, M; Huang, X; Xiong, B Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy. J Med Chem64:16650-16674 (2021) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone-arginine methyltransferase CARM1 |
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| Name: | Histone-arginine methyltransferase CARM1 |
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| Synonyms: | CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4) |
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| Type: | Protein |
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| Mol. Mass.: | 65855.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q86X55 |
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| Residue: | 608 |
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| Sequence: | MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEV
RAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSF
YNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNH
TDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPG
KVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDE
QLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFL
EAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRC
LFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTT
PSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLAN
TGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIP
TNTMHYGS
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| BDBM50609312 |
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| n/a |
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| Name | BDBM50609312 |
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| Synonyms: | CHEMBL5273938 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H32F3N5O2 |
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| Mol. Mass. | 515.5705 |
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| SMILES | CNCCNCc1cccc(c1)-c1nc(NC2CCOCC2)c(C)c(n1)-c1ccc(OC(F)(F)F)cc1 |
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| Structure | 
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