| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII/Tissue factor |
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| Ligand | BDBM50197341 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_432199 (CHEMBL904425) |
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| IC50 | 2400±n/a nM |
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| Citation |  Miura, M; Seki, N; Koike, T; Ishihara, T; Niimi, T; Hirayama, F; Shigenaga, T; Sakai-Moritani, Y; Tagawa, A; Kawasaki, T; Sakamoto, S; Okada, M; Ohta, M; Tsukamoto, S Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands. Bioorg Med Chem15:160-73 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor VII/Tissue factor |
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| Name: | Coagulation factor VII/Tissue factor |
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| Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 69535 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tissue factor |
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| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33067.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_936735 |
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| Residue: | 295 |
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| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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| Component 2 |
| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM50197341 |
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| n/a |
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| Name | BDBM50197341 |
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| Synonyms: | 2'-({[3-(aminocarbonyl)phenyl]amino}carbonyl)-4-{[((1S)-carboxy-3-methylbutyl)amino]carbonyl}biphenyl-2-carboxylic acid | CHEMBL224925 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O7 |
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| Mol. Mass. | 517.5299 |
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| SMILES | CC(C)C[C@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1ccccc1C(=O)Nc1cccc(c1)C(N)=O)C(O)=O |
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| Structure | 
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