| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 4 |
|---|
| Ligand | BDBM50198426 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_440952 (CHEMBL890042) |
|---|
| IC50 | 280±n/a nM |
|---|
| Citation |  Purandare, AV; Wan, H; Somerville, JE; Burke, C; Vaccaro, W; Yang, X; McIntyre, KW; Poss, MA Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett17:679-82 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 4 |
|---|
| Name: | C-C chemokine receptor type 4 |
|---|
| Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41406.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51679 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
|
|
|
|---|
| BDBM50198426 |
|---|
| n/a |
|---|
| Name | BDBM50198426 |
|---|
| Synonyms: | CHEMBL233047 | N4-(2,4-dichlorobenzyl)-N2-(4-(diethylamino)pentyl)pyrimidine-2,4-diamine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H29Cl2N5 |
|---|
| Mol. Mass. | 410.384 |
|---|
| SMILES | CCN(CC)C(C)CCCNc1nccc(NCc2ccc(Cl)cc2Cl)n1 |w:5.5| |
|---|
| Structure | 
|
|---|
Search and Browse
