Ki Summary

Reaction Details

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Target

Glucagon receptor

Ligand

BDBM50199494

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_441038 (CHEMBL890125)

IC50

3380±n/a nM

Citation

Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett17:587-92 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Glucagon receptor

Name:

Glucagon receptor

Synonyms:

GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)

Type:

Enzyme

Mol. Mass.:

54026.92

Organism:

Homo sapiens (Human)

Description:

P47871

Residue:

477

Sequence:

MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF

BDBM50199494

n/a

Name

BDBM50199494

Synonyms:

3-(1-(1-(cis-4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-indene-5-carboxamido)propanoic acid | CHEMBL398180

Type

Small organic molecule

Emp. Form.

C31H38F3N3O5

Mol. Mass.

589.6457

SMILES

CC(C)(C)[C@@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)NCCC(O)=O)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wD:4.3,7.10,(-1.63,-20.96,;-1.62,-19.43,;-.08,-19.43,;-3.16,-19.42,;-1.61,-17.89,;-2.94,-17.11,;-2.94,-15.58,;-1.59,-14.81,;-.27,-15.57,;-.28,-17.12,;-1.59,-13.27,;-.26,-12.5,;.06,-11,;1.92,-11.03,;2.39,-12.49,;3.73,-13.25,;3.73,-14.8,;2.4,-15.57,;1.07,-14.8,;1.07,-13.27,;5.07,-15.57,;5.07,-17.11,;6.4,-14.8,;7.74,-15.56,;9.07,-14.79,;10.4,-15.56,;11.74,-14.78,;10.41,-17.1,;-2.93,-12.5,;-2.93,-10.96,;-4.26,-13.27,;-5.6,-12.5,;-6.94,-13.28,;-8.27,-12.5,;-8.27,-10.96,;-9.6,-10.19,;-9.6,-8.65,;-9.62,-7.11,;-8.06,-8.64,;-11.14,-8.66,;-6.94,-10.19,;-5.6,-10.95,)|

Structure