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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucagon receptor | ||
| Ligand | BDBM50199495 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_441038 (CHEMBL890125) | ||
| IC50 | 4.9±n/a nM | ||
| Citation |  Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett17:587-92 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucagon receptor | |||
| Name: | Glucagon receptor | ||
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54026.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P47871 | ||
| Residue: | 477 | ||
| Sequence: |
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| BDBM50199495 | |||
| n/a | |||
| Name | BDBM50199495 | ||
| Synonyms: | 1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)-1-((1r,4r)-4-tert-butylcyclohexyl)-3-(3,5-dichlorophenyl)urea | CHEMBL232448 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H33Cl2N7O2 | ||
| Mol. Mass. | 570.513 | ||
| SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1cc(Cl)cc(Cl)c1 |w:11.11,wU:7.10,wD:4.3,(23.03,-6.29,;23.04,-4.75,;24.58,-4.76,;21.5,-4.75,;23.05,-3.21,;24.38,-2.44,;24.39,-.9,;23.06,-.14,;21.72,-.9,;21.71,-2.44,;23.06,1.4,;24.4,2.17,;24.72,3.67,;26.58,3.64,;27.05,2.18,;28.38,1.42,;28.39,-.13,;27.06,-.9,;25.72,-.13,;25.73,1.41,;29.73,-.9,;29.73,-2.44,;31.06,-.12,;32.39,-.89,;32.56,-2.42,;34.06,-2.74,;34.83,-1.4,;33.8,-.26,;21.73,2.17,;21.73,3.71,;20.4,1.4,;19.06,2.17,;19.05,3.72,;17.71,4.48,;17.71,6.02,;16.39,3.71,;16.39,2.17,;15.05,1.4,;17.72,1.4,)| | ||
| Structure | 
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