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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Glucagon receptor | ||
| Ligand | BDBM50199492 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_441038 (CHEMBL890125) | ||
| IC50 | 359±n/a nM | ||
| Citation |  Liang, R; Abrardo, L; Brady, EJ; Candelore, MR; Ding, V; Saperstein, R; Tota, LM; Wright, M; Mock, S; Tamvakopolous, C; Tong, S; Zheng, S; Zhang, BB; Tata, JR; Parmee, ER Design and synthesis of conformationally constrained tri-substituted ureas as potent antagonists of the human glucagon receptor. Bioorg Med Chem Lett17:587-92 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Glucagon receptor | |||
| Name: | Glucagon receptor | ||
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 54026.92 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P47871 | ||
| Residue: | 477 | ||
| Sequence: |
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| BDBM50199492 | |||
| n/a | |||
| Name | BDBM50199492 | ||
| Synonyms: | 1-(5-((2H-tetrazol-5-yl)carbamoyl)-2,3-dihydro-1H-inden-1-yl)-1-((1r,4r)-4-tert-butylcyclohexyl)-3-(4-(trifluoromethoxy)phenyl)urea | CHEMBL396215 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H34F3N7O3 | ||
| Mol. Mass. | 585.6206 | ||
| SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)N(C1CCc2cc(ccc12)C(=O)Nc1nnn[nH]1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:11.11,wU:7.10,wD:4.3,(22.92,-7.75,;22.93,-6.22,;24.47,-6.22,;21.39,-6.21,;22.93,-4.68,;24.27,-3.91,;24.28,-2.36,;22.95,-1.6,;21.61,-2.37,;21.6,-3.9,;22.95,-.06,;24.29,.71,;24.6,2.21,;26.46,2.18,;26.94,.72,;28.27,-.04,;28.28,-1.59,;26.94,-2.36,;25.61,-1.59,;25.62,-.06,;29.61,-2.36,;29.62,-3.9,;30.95,-1.59,;32.28,-2.35,;32.45,-3.88,;33.95,-4.2,;34.72,-2.86,;33.69,-1.72,;21.62,.71,;21.62,2.25,;20.28,-.06,;18.95,.71,;17.61,-.07,;16.28,.71,;16.28,2.25,;14.94,3.02,;14.94,4.56,;14.93,6.1,;16.48,4.57,;13.4,4.55,;17.6,3.02,;18.94,2.26,)| | ||
| Structure | 
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