| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-8 |
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| Ligand | BDBM50199762 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_441112 (CHEMBL891326) |
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| IC50 | 448±n/a nM |
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| Citation |  Wang, Y; O'Neil, SV; Wos, JA; Oppong, KA; Laufersweiler, MC; Soper, DL; Ellis, CD; Baize, MW; Fancher, AN; Lu, W; Suchanek, MK; Wang, RL; Schwecke, WP; Cruze, CA; Buchalova, M; Belkin, M; De, B; Demuth, TP Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors. Bioorg Med Chem15:1311-22 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-8 |
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| Name: | Caspase-8 |
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| Synonyms: | Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog |
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| Type: | Enzyme |
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| Mol. Mass.: | 55373.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14790 |
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| Residue: | 479 |
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| Sequence: | MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
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| BDBM50199762 |
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| n/a |
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| Name | BDBM50199762 |
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| Synonyms: | CHEMBL411178 | N-((S,Z)-1-(2-((3S)-2-hydroxy-5-oxo-tetrahydrofuran-3-ylamino)-2-oxoethyl)-6-((3-methoxybenz-amido)-methyl)-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-2-naphthamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H32N4O8 |
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| Mol. Mass. | 600.6185 |
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| SMILES | COc1cccc(c1)C(=O)NCC1=CC[C@H](NC(=O)c2ccc3ccccc3c2)C(=O)N(CC(=O)N[C@H]2CC(=O)OC2O)C1 |w:41.45,t:13| |
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| Structure | 
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