| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
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| Ligand | BDBM2582 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422396 (CHEMBL908188) |
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| IC50 | >50000±n/a nM |
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| Citation |  Trapp, J; Jochum, A; Meier, R; Saunders, L; Marshall, B; Kunick, C; Verdin, E; Goekjian, P; Sippl, W; Jung, M Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem49:7307-16 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-1 |
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| Name: | NAD-dependent protein deacetylase sirtuin-1 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
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| Type: | Developmental protein; hydrolase |
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| Mol. Mass.: | 81626.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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| BDBM2582 |
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| n/a |
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| Name | BDBM2582 |
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| Synonyms: | 3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyrrole-2,5-dione | Bisindolylmaleimide deriv. 4 | CHEMBL291725 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H15N3O2 |
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| Mol. Mass. | 341.3627 |
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| SMILES | CN1C(=O)C(=C(C1=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12 |c:4| |
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| Structure | 
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