| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Nek2 |
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| Ligand | BDBM47167 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_420191 (CHEMBL912734) |
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| IC50 | >100000±n/a nM |
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| Citation |  Peifer, C; Krasowski, A; Hämmerle, N; Kohlbacher, O; Dannhardt, G; Totzke, F; Schächtele, C; Laufer, S Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor. J Med Chem49:7549-53 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Nek2 |
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| Name: | Serine/threonine-protein kinase Nek2 |
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| Synonyms: | NEK kinase | NEK2 | NEK2A | NEK2_HUMAN | NLK1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 51776.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51955 |
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| Residue: | 445 |
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| Sequence: | MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLR
ELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQL
TLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP
YYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY
SDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSS
PVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKE
RKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAA
QLRAQALSDIEKNYQLKSRQILGMR
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| BDBM47167 |
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| n/a |
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| Name | BDBM47167 |
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| Synonyms: | CHEMBL201511 | US8957103, Z1 | US9364459, A |
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| Type | n/a |
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| Emp. Form. | C21H18N2O5 |
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| Mol. Mass. | 378.378 |
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| SMILES | COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12 |t:13| |
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| Structure | 
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