| Reaction Details |
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 | Report a problem with these data |
| Target | Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Ligand | BDBM146127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2300367 |
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| IC50 | 10.0±n/a nM |
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| Citation |  Levell, JR; Caferro, T; Chenail, G; Dix, I; Dooley, J; Firestone, B; Fortin, PD; Giraldes, J; Gould, T; Growney, JD; Jones, MD; Kulathila, R; Lin, F; Liu, G; Mueller, A; van der Plas, S; Slocum, K; Smith, T; Terranova, R; Touré, BB; Tyagi, V; Wagner, T; Xie, X; Xu, M; Yang, FS; Zhou, LX; Pagliarini, R; Cho, YS Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett8:151-156 (2017) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Name: | Isocitrate dehydrogenase [NADP] cytoplasmic |
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| Synonyms: | Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD |
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| Type: | Protein |
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| Mol. Mass.: | 46661.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75874 |
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| Residue: | 414 |
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| Sequence: | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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| BDBM146127 |
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| n/a |
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| Name | BDBM146127 |
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| Synonyms: | US8957068, 162 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N4O3 |
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| Mol. Mass. | 418.4882 |
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| SMILES | CC(C)[C@H]1COC(=O)N1c1ccnc(N[C@@H](C)c2ccc(Oc3ccccc3)cc2)n1 |r| |
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| Structure | 
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