Ki Summary

Reaction Details

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Target

Corticotropin-releasing factor receptor 1

Ligand

BDBM50203620

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_454261 (CHEMBL903444)

1400±n/a nM

Citation

Han, X; Civiello, R; Pin, SS; Burris, K; Balanda, LA; Knipe, J; Ren, S; Fiedler, T; Browman, KE; Macci, R; Taber, MT; Zhang, J; Dubowchik, GM An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes. Bioorg Med Chem Lett17:2026-30 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Corticotropin-releasing factor receptor 1

Name:

Corticotropin-releasing factor receptor 1

Synonyms:

Type:

Enzyme

Mol. Mass.:

50744.31

Organism:

Homo sapiens (Human)

Description:

P34998

Residue:

444

Sequence:

MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV

BDBM50203620

n/a

Name

BDBM50203620

Synonyms:

8-(2-chloro-4,6-dimethyl-phenyl)-2-methyl-3-morpholin-4-ylmethyl-8H-1,3a,7,8-tetraaza-cyclopenta[a]indene | CHEMBL440232

Type

Small organic molecule

Emp. Form.

C22H24ClN5O

Mol. Mass.

409.912

SMILES

Cc1nc2n(-c3c(C)cc(C)cc3Cl)c3ncccc3n2c1CN1CCOCC1 |(-8.79,-40.1,;-7.37,-39.52,;-6.06,-40.33,;-4.88,-39.35,;-3.34,-39.24,;-2.35,-40.42,;-.84,-40.15,;-.32,-38.7,;.15,-41.32,;-.38,-42.78,;.61,-43.96,;-1.9,-43.04,;-2.89,-41.86,;-4.4,-42.13,;-2.97,-37.75,;-1.6,-37.03,;-1.54,-35.48,;-2.92,-34.59,;-4.22,-35.38,;-4.28,-36.92,;-5.46,-37.91,;-7,-38.03,;-7.99,-36.85,;-7.46,-35.4,;-5.95,-35.14,;-5.43,-33.7,;-6.41,-32.52,;-7.93,-32.78,;-8.46,-34.23,)|

Structure