| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-B receptor 3 |
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| Ligand | BDBM50205477 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_442377 (CHEMBL892539) |
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| Ki | >2000±n/a nM |
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| Citation |  Chen, S; Chen, L; Le, NT; Zhao, C; Sidduri, A; Lou, JP; Michoud, C; Portland, L; Jackson, N; Liu, JJ; Konzelmann, F; Chi, F; Tovar, C; Xiang, Q; Chen, Y; Wen, Y; Vassilev, LT Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors. Bioorg Med Chem Lett17:2134-8 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ephrin type-B receptor 3 |
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| Name: | Ephrin type-B receptor 3 |
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| Synonyms: | EPHB3 | EPHB3_HUMAN | ETK2 | Ephrin receptor | Ephrin type-B receptor 3 | Ephrin type-B receptor 3 (EPHB3) | HEK2 | TYRO6 | Tyrosine Kinase EPHB3 |
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| Type: | Protein |
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| Mol. Mass.: | 110326.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P54753 |
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| Residue: | 998 |
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| Sequence: | MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPES
GWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIP
NIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRS
FGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGT
CIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGP
CLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWS
EPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTR
YTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPN
GVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEF
ETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQY
IAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREV
FVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALD
SFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLS
RFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYW
DMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAA
SLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQM
TAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV
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| BDBM50205477 |
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| n/a |
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| Name | BDBM50205477 |
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| Synonyms: | (Z)-2-((1R,2S)-2-phenylcyclopropylamino)-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one | CHEMBL235345 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17N3OS |
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| Mol. Mass. | 371.455 |
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| SMILES | O=C1N=C(N[C@@H]2C[C@H]2c2ccccc2)SC1=Cc1ccc2ncccc2c1 |w:16.19,t:2| |
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| Structure | 
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