Reaction Details |
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Target | Cyclin-dependent kinase 1 |
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Ligand | BDBM50205468 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_442382 (CHEMBL892544) |
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IC50 | 2840±n/a nM |
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Citation | Chen, S; Chen, L; Le, NT; Zhao, C; Sidduri, A; Lou, JP; Michoud, C; Portland, L; Jackson, N; Liu, JJ; Konzelmann, F; Chi, F; Tovar, C; Xiang, Q; Chen, Y; Wen, Y; Vassilev, LT Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors. Bioorg Med Chem Lett17:2134-8 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 1 |
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Name: | Cyclin-dependent kinase 1 |
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 34101.08 |
Organism: | Homo sapiens (Human) |
Description: | P06493 |
Residue: | 297 |
Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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BDBM50205468 |
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n/a |
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Name | BDBM50205468 |
Synonyms: | (Z)-2-amino-5-(quinolin-6-ylmethylene)thiazol-4(5H)-one | CHEMBL396377 |
Type | Small organic molecule |
Emp. Form. | C13H9N3OS |
Mol. Mass. | 255.295 |
SMILES | NC1=NC(=O)C(S1)=Cc1ccc2ncccc2c1 |w:7.8,t:1| |
Structure |
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