Reaction Details |
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Target | Chymase |
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Ligand | BDBM50208220 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_429291 (CHEMBL915852) |
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IC50 | 240±n/a nM |
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Citation | Greco, MN; Hawkins, MJ; Powell, ET; Almond, HR; de Garavilla, L; Hall, J; Minor, LK; Wang, Y; Corcoran, TW; Di Cera, E; Cantwell, AM; Savvides, SN; Damiano, BP; Maryanoff, BE Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem50:1727-30 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chymase |
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Name: | Chymase |
Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
Type: | Enzyme |
Mol. Mass.: | 27340.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 247 |
Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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BDBM50208220 |
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n/a |
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Name | BDBM50208220 |
Synonyms: | 1-(5-chlorobenzo[b]thiophen-3-yl)-2-(naphthalen-2-ylamino)-2-oxoethyl(phenethyl)phosphinic acid | CHEMBL373820 |
Type | Small organic molecule |
Emp. Form. | C28H23ClNO3PS |
Mol. Mass. | 519.979 |
SMILES | OP(=O)(CCc1ccccc1)C(C(=O)Nc1ccc2ccccc2c1)c1csc2ccc(Cl)cc12 |
Structure |
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