| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 1 |
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| Ligand | BDBM50208997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_443413 (CHEMBL893666) |
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| IC50 | 480±n/a nM |
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| Citation |  Brown, MF; Bahnck, KB; Blumberg, LC; Brissette, WH; Burrell, SA; Driscoll, JP; Fedeles, F; Fisher, MB; Foti, RS; Gladue, RP; Guzman-Martinez, A; Hayward, MM; Lira, PD; Lillie, BM; Lu, Y; Lundquist, GD; McElroy, EB; McGlynn, MA; Paradis, TJ; Poss, CS; Roache, JH; Shavnya, A; Shepard, RM; Trevena, KA; Tylaska, LA Piperazinyl CCR1 antagonists--optimization of human liver microsome stability. Bioorg Med Chem Lett17:3109-12 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 1 |
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| Name: | C-C chemokine receptor type 1 |
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| Synonyms: | C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41180.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32246 |
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| Residue: | 355 |
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| Sequence: | METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLV
QYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTH
HTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRL
IFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVI
YAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
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| BDBM50208997 |
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| n/a |
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| Name | BDBM50208997 |
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| Synonyms: | CHEMBL234606 | N-((2S,3S,5R)-5-(aminomethyl)-1-(3-fluorophenyl)-3,8-dihydroxy-8-methylnonan-2-yl)quinoxaline-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H33FN4O3 |
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| Mol. Mass. | 468.5636 |
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| SMILES | CC(C)(O)CC[C@@H](CN)C[C@H](O)[C@H](Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1 |
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| Structure | 
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