Reaction Details |
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Target | B1 bradykinin receptor |
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Ligand | BDBM50209723 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_434360 (CHEMBL919419) |
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Ki | 367±n/a nM |
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Citation | Biswas, K; Li, A; Chen, JJ; D'Amico, DC; Fotsch, C; Han, N; Human, J; Liu, Q; Norman, MH; Riahi, B; Yuan, C; Suzuki, H; Mareska, DA; Zhan, J; Clarke, DE; Toro, A; Groneberg, RD; Burgess, LE; Lester-Zeiner, D; Biddlecome, G; Manning, BH; Arik, L; Dong, H; Huang, M; Kamassah, A; Loeloff, R; Sun, H; Hsieh, FY; Kumar, G; Ng, GY; Hungate, RW; Askew, BC; Johnson, E Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides. J Med Chem50:2200-12 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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B1 bradykinin receptor |
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Name: | B1 bradykinin receptor |
Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
Type: | Enzyme |
Mol. Mass.: | 40508.87 |
Organism: | Homo sapiens (Human) |
Description: | P46663 |
Residue: | 353 |
Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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BDBM50209723 |
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n/a |
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Name | BDBM50209723 |
Synonyms: | (R)-N-((R)-7-((tert-butylamino)methyl)chroman-4-yl)-3-phenyl-3-(2-(trifluoromethyl)phenylsulfonamido)propanamide | CHEMBL227697 |
Type | Small organic molecule |
Emp. Form. | C30H34F3N3O4S |
Mol. Mass. | 589.669 |
SMILES | CC(C)(C)NCc1ccc2[C@@H](CCOc2c1)NC(=O)C[C@@H](NS(=O)(=O)c1ccccc1C(F)(F)F)c1ccccc1 |
Structure |
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