| Reaction Details |
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 | Report a problem with these data |
| Target | Chymase |
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| Ligand | BDBM50210114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_455355 (CHEMBL886130) |
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| IC50 | 280±n/a nM |
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| Citation |  Tanaka, T; Muto, T; Maruoka, H; Imajo, S; Fukami, H; Tomimori, Y; Fukuda, Y; Nakatsuka, T Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett17:3431-4 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chymase |
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| Name: | Chymase |
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| Synonyms: | Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I |
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| Type: | Enzyme |
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| Mol. Mass.: | 27340.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 247 |
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| Sequence: | MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
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| BDBM50210114 |
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| n/a |
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| Name | BDBM50210114 |
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| Synonyms: | 6-(2-butoxy-5-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-diazepane-2,5-dione | CHEMBL395822 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24Cl2N2O5S |
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| Mol. Mass. | 499.407 |
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| SMILES | CCCCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 |
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| Structure | 
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