| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50214547 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456336 (CHEMBL888347) |
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| IC50 | 151±n/a nM |
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| Citation |  Léger, S; Bayly, CI; Black, WC; Desmarais, S; Falgueyret, JP; Massé, F; Percival, MD; Truchon, JF Primary amides as selective inhibitors of cathepsin K. Bioorg Med Chem Lett17:4328-32 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50214547 |
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| n/a |
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| Name | BDBM50214547 |
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| Synonyms: | (S)-4-methyl-2-[(S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)-ethylamino]-pentanoic acid ((S)-1-carbamoyl-3-methanesulfonyl-propyl)-amide | CHEMBL250293 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34F3N3O6S2 |
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| Mol. Mass. | 605.69 |
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| SMILES | CC(C)C[C@H](N[C@@H](c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O)C(F)(F)F)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O |
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| Structure | 
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