| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50216157 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448369 (CHEMBL898630) |
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| IC50 | 440±n/a nM |
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| Citation |  Hugon, B; Anizon, F; Bailly, C; Golsteyn, RM; Pierré, A; Léonce, S; Hickman, J; Pfeiffer, B; Prudhomme, M Synthesis and biological activities of isogranulatimide analogues. Bioorg Med Chem15:5965-80 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50216157 |
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| n/a |
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| Name | BDBM50216157 |
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| Synonyms: | 11H-2,5,11,11b-Tetraaza-benzo[a]trindene-4,6-dione | 3,11-dihydro-2,5,11,11b-tetraaza-benzo[a]trindene-4,6-dione | CHEMBL413188 | isogranulatimide |
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| Type | Small organic molecule |
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| Emp. Form. | C15H8N4O2 |
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| Mol. Mass. | 276.2496 |
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| SMILES | O=C1NC(=O)c2c1c1cncn1c1[nH]c3ccccc3c21 |
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| Structure | 
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